During Their Lifetimes, One in Three Women will Break Their Hip Bones(1)
This is preventable. The health of your bones can be evaluated with a urine test.

A Case in Point
A woman in her fifties showed significant bone loss on both x-rays and a urine test. A post-menopausal salivary hormone test was done. She was found to be deficient in three hormones. Her doctor gave her a balanced hormone regimen. Nine months later, her bone urine test was normal.

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Bone Health Panel: Patient Overview

What Is Bone Aging?

Bone turnover is a process that takes place throughout our lifetimes. It is a delicate balance between bone formation and breakdown. In childhood and early adulthood, the process is strongly in favor of bone formation, and this continues up to the age of 20 to 30 years. From then on, there is a gradual thinning and loss of bone with age. Around the onset of menopause, bone turnover tilts in favor of bone breakdown. This is due to the persistent imbalance or decline in estrogen, progesterone, and other hormones.

How Is It Related to Menopause?

During cycling years most women have enough ovarian output of progesterone and estrogen. These two hormones promote bone growth. Around the mid-forties (usually 3 to 4 years before cessation of menstruation), the levels of estrogen and progesterone start to gradually drop off, thus accelerating bone dissolution. In men, the decrease in testosterone can lead to a similar picture.

Does It Affect My Health?

Yes, it does.

Bone aging leads to a disease called osteoporosis that results in bone thinning and, more importantly, bone fragility. Osteoporosis can affect you and your loved ones in several ways:

  • Middle-aged and elderly people lose a few inches of their height due to osteoporosis.
  • Many seniors are prone to hip fractures secondary to osteoporosis.
  • 1.5 million bone fractures, at various body sites, occur annually secondary to osteoporosis.

Am I at Risk for Osteoporosis?

Your risk for osteoporosis increases with:
  • Age
  • Sedentary lifestyle
  • Fair complexion
  • Low body weight
  • Smoking
  • Alcohol consumption
  • Family history of osteoporosis
  • Long term glucocorticoid or steroid therapy
  • The onset of menopause...
Your risk also increases if you have any of the following conditions:
  • Thyroid disease
  • Diabetes
  • Kidney disease
  • Rheumatoid arthritis
  • Premature ovarian failure
  • History of an eating disorder
  • Celiac disease
  • Inflammatory bowel disease
  • Low vitamin D levels
  • Dementia

If you are at a high risk for developing osteoporosis, your physician has different options to assess your risks. These include:

  • Bone Density Measurement—Employs x-rays to measure your bone strength and mineral content.
  • Urine Testing—Uses one urine specimen to assess the rate of bone breakdown in your body.

What Does Diagnos-Techs Offer?

We offer the Pyrilinks-D (DPD) urine test, which assesses bone breakdown, in combination with a saliva test that measures hormone levels of estrogen, progesterone, DHEA, FSH, testosterone, and cortisol.

Uses for the Bone Health Panel

Your doctor can use the Pyrilinks-D urine test within this panel to:

  • Screen for osteoporosis in conjunction with bone densitometry.
  • As a follow-up test to monitor the bone response in hormone replacement therapy and/ or osteoporosis treatment protocols.

Monitoring hormone replacement therapy through our lab also includes salivary hormone measurements of estradiol, estrone, estriol, progesterone, DHEA, and testosterone—all from one salivary sample (PostM™ or PeriM™).