Post Menopausal Tests - Other Related Tests
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DHEA Challenge Test - DCT

Specimens: Four saliva specimens are collected. The first sample is a random baseline measurement of DHEA, Testosterone and Estradiol. It is then followed by a 5-6 day challenge with DHEA. The second sample is collected on the last day of the challenge.

(Refer to Technical Bulletin 5 for instructions)

Target Population
The DCT is used in women and men who suffer from Estrogen and/or Testosterone dependent/associated pathologies, as shown in the table below

Women	Men
Cystic breast disease	Gynecomastia
Breast Cancer	Prostate problems
Uterine Cancer	Testicular Atrophy
Uterine Polyps & Firbroids	Low sperm count
Endometrial Hypertrophy	Libido reduction
Endometriosis
Hirsutism
Masculinization
Libido reduction

Hormones Tested
DHEA, Testosterone, and Estradiol are measured in both samples. The post challenge
(2nd Sample) collection is used to determine DHEA levels and its conversion efficiency to downstream hormones (ex. Testosterone and Estradiol).

Clinical Use
Description: This test is intended for individuals who have low DHEA levels and would like to supplement with exogenous DHEA. However, there is a concern that DHEA may be excessively converted to Testosterone or Estradiol. Conversion efficiencies are a phenotypic expression and can vary from person to person.

Examples: Women with uterine fibroids can be tested to determine if supplemental DHEA is
converting to estrogens, which promote fibroid growth.

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6620 South 192nd Place, Building J
Kent, Washington 98032
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