Literature References

Saliva has proven to be an easy to collect and reliable sample source for many biological studies. In some cases, it is even superior to other body fluids for measuring biomarker levels. This section lists references for those wishing additional information on the utility of saliva testing.

“Salivary levels of steroid hormones and other analytes that are protein bound in serum reflect the unbound and active concentration of the hormone. Saliva can be used as a diagnostic specimen not only to obtain information more inexpensively and efficiently than serum, but also to provide information not readily available from serum testing.” J. Nutr. 131: 1621S–1625S, 2001.

“Although saliva has not yet become a mainstream sample source for hormone analysis, it has proven to be reliable and, in some cases, even superior to other body fluids”. Clin Chem 2008; 54:11 1759-1769.

“Recent studies have demonstrated that late-night salivary cortisol measurements provide a sensitivity and specificity for the diagnosis of Cushing’s syndrome of more than 90%, and this procedure is emerging as possibly the simplest and most effective screening tool for patients in whom the diagnosis of hypercotisolism is suspected”. Greenspan’s Basic & Clinical Endocrinology 8Th ed. 2007 page 364.

“We recommend initial use of one test with high diagnostic accuracy…late night salivary cortisol…” Endocrine Society Clinical Practice Guideline 2008.

The following links will direct you to the abstract summary of the articles listed. These articles are obtained from the U.S. National Library of Medicine and National Institutes of Health.

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General
Aldosterone
Androstenedione
Antigliadin Antibody IgA
Cortisol
Dehydroepiandrosterone [DHEA and DHEA(s)]
Follicle Stimulating (FSH) & Lutenizing (LH)
Immunoglobulin A (IgA)
Melatonin
Progesterone
Testosterone & Dihydrotestosterone (DHT)