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March Newsletter
Allergy Season Starts in the Gut
Help your patients breathe easier this allergy season by looking beyond the lungs and exploring an often-overlooked contributor to immune and pulmonary health: the gut microbiome.
Emerging research continues to highlight the powerful connection between gut health, immune regulation, and pulmonary function. When the gut microbiome is balanced and diverse, it may modulate immune responses, reduce inflammation, and support healthier respiratory outcomes – factors that are especially important for patients struggling with seasonal allergies and related respiratory symptoms.1
By evaluating and optimizing the health of the gut microbiome, physicians have an additional pathway to support patients experiencing allergic inflammation, airway sensitivity, and immune dysregulation. Addressing gut health may improve the body’s ability to respond to environmental allergens and promote resilient respiratory function.1
Featured News Article
Asthma & The Gut Microbiome ~ The Gut-Lung Axis
Hippocrates, widely regarded as the “Father of Medicine,” stated more than two thousand years ago that “all disease begins in the gut.” Today, an abundance of research suggests that this observation was remarkably prescient. We now recognize that the gut microbiome and its metabolites, particularly short-chain fatty acids (SCFAs), play an important role in immune regulation and may influence the development of chronic conditions, including pulmonary diseases.1
Animal studies suggest that a high-fiber diet increases SCFA production by the gut microbiota, which may modulate immune responses associated with allergic airway disease.
According to the data, higher SCFA levels correlate with:
- Reduced IgA, IgG, and IgE antibody levels
- Decreased airway mucus production
- Protection against allergic inflammation in the lungs1
Preclinical studies further demonstrate that butyrate supplementation reduces eosinophils, inflammatory infiltrates, and mucus production in the lungs, supporting the role of gut-derived metabolites in respiratory immunomodulation.1
Learn more about the Gut-Lung Axis and the potential clinical implications in our featured article below.
Asthma & The Gut Microbiome
Top Test Panel Spotlight
Flexi-Matrix Combo
Ordering an Expanded ASI but also interested in assessing gastrointestinal health?
The Flexi-Matrix Combo test panel allows clinicians to combine cortisol, insulin, food sensitivity, DHEA, and additional saliva-based biomarkers with comprehensive gut health testing in a single, customizable panel.
Integrate gut, immune, and hormone testing into your patient assessment with a customizable Flexi-Matrix panel!
Build and manage your custom Flexi panels here →
Customize a Flexi-Matrix Combo Test Panel
Resources available in your Provider Portal:
- Sample Reports, including the Expanded GI Health Panel™ with GP3x and Calprotectin
- Provider Tools, including:
- Test & Fee Schedule
- Book a Medical Support Consultation Online
~ We look forward to hearing from you! ~
If you have questions or need to order test kits, please call 1-800-878-3787 or email [email protected] at your earliest convenience.
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Explore the Gut-Lung Axis
¹ DiagnosTechs, 2026. Asthma & the Gut Microbiome ~ The Gut-Lung Axis